2:45 pm Optimizing MASH Combination Therapy Trials Through Novel Composite Endpoints to Enhance Sensitivity & Demonstrate Long-Term Clinical Benefit
Time: 2:45 pm
day: Combination & Sequential Therapy Focus Day
Details:
- Employing composite endpoints to capture multiple dimensions of MASH resolution (steatosis, inflammation, fibrosis) to provide a more holistic measure of treatment efficacy in combination therapy trials
- Applying time-to-event analyses to composite endpoints to demonstrate the long-term benefits of MASH combination therapies for clinically relevant outcomes
- Incorporating patient-reported outcomes (PROs) into composite endpoints to ensure that the patient experience is adequately captured in MASH clinical trials to progress to a more patient-centred approach to drug development
