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Seminars
Monday 29th September 2025
9:45 am Myeloid Cells Orchestrate Fibrosis in MASH: A Call to Refocus Therapeutic Targeting Beyond Adaptive Immunity
- Investigating immune-mediated mechanisms driving fibrosis in MASH, with emphasis on the interplay between innate and adaptive immune cells
- Identifying myeloid cells as essential architects of the fibrotic niche, promoting bystander T-cell accumulation and activating myofibroblasts
- Supporting reorienting anti-fibrotic strategies toward targeting innate immune and stromal components, based on integrated analyses from human and preclinical models
Monday 29th September 2025
12:30 pm Roundtable Discussion: Synthesizing Novel Mechanisms to Chart the Future of MASH Therapeutic Strategies for Continued Innovation
- Synthesizing learnings from the diverse mechanisms of action presentations for a holistic understanding of MASH pathophysiology to enable the identification of convergent pathways and novel, synergistic drug targets
- Debating the most promising emerging mechanisms to provide a platform for critical evaluation and prioritization of research efforts for guiding strategic investment, and accelerating the development of high-impact MASH therapies
- Identifying opportunities for multi-targeted or combination approaches based on mechanistic insights to foster innovative thinking beyond single-target therapies for designing more effective MASH treatments
