Marie O’Farrell
Seminars
Monday 29th September 2025
3.15 pm Panel Discussion: Designing Therapies with Novel Mechanisms & Predictive Biomarkers to Holistically Improve Treatment for Better Patient Outcomes
- Integrating the design of therapies involving novel mechanisms with new, predictive biomarkers to provide a more precise and efficient approach to drug discovery and development for earlier identification of responders and non-responders
- Leveraging cutting-edge understanding of MASH pathogenesis to design innovative therapies to target the root causes of the disease for more effective treatments that can holistically improve patient outcomes
- Developing and validating novel predictive biomarkers alongside new therapeutic candidates for early and accurate identification of patient response for more streamlined clinical trials and impactful MASH therapies
Monday 29th September 2025
2:45 pmHighlighting Mechanism of Action of FASN Inhibitor Denifanstat in MASH
- Reviewing preclinical activity of FASN inhibitor combined with semaglutide or resmetirom
- Highlighting efficacy of denifanstat added to background GLP1 treatment in Ph2b FASCINATE-2
- Planning Phase 1 PK assessment of denifanstat and resmetirom
