Marie O’Farrell
Company: Sagimet Biosciences
Job title: Senior Vice President, Research & Development
Seminars:
3.15 pm Panel Discussion: Designing Therapies with Novel Mechanisms & Predictive Biomarkers to Holistically Improve Treatment for Better Patient Outcomes 3:15 pm
Integrating the design of therapies involving novel mechanisms with new, predictive biomarkers to provide a more precise and efficient approach to drug discovery and development for earlier identification of responders and non-responders Leveraging cutting-edge understanding of MASH pathogenesis to design innovative therapies to target the root causes of the disease for more effective treatments that…Read more
day: Combination & Sequential Therapy Focus Day
2:45 pm Optimizing MASH Combination Therapy Trials Through Novel Composite Endpoints to Enhance Sensitivity & Demonstrate Long-Term Clinical Benefit 2:45 pm
Employing composite endpoints to capture multiple dimensions of MASH resolution (steatosis, inflammation, fibrosis) to provide a more holistic measure of treatment efficacy in combination therapy trials Applying time-to-event analyses to composite endpoints to demonstrate the long-term benefits of MASH combination therapies for clinically relevant outcomes Incorporating patient-reported outcomes (PROs) into composite endpoints to ensure that…Read more
day: Combination & Sequential Therapy Focus Day